Disintegrant Properties of Native Starches obtained from Cassava, Sweet Potato and Corn in Ibuprofen Tablet Formulations
نویسندگان
چکیده
منابع مشابه
Evaluation of the Disintegrant Properties of Native Starches of Five New Cassava Varieties in Paracetamol Tablet Formulations
The disintegrant potential of native starches of five new cassava (Manihot esculenta Crantz.) varieties developed by the Crops Research Institute of Ghana (CRIG) was studied in paracetamol tablet formulations. The yield of the starches ranged from 8.0 to 26.7%. The starches were basic (pH: 8.1-9.9), with satisfactory moisture content (≤15%), swelling capacity (≥20%), ash values (<1%), flow prop...
متن کاملStudy on tablet binding and disintegrating properties of alternative starches prepared from taro and sweet potato tubers.
To demonstrate the potential alternative sources of starch used in tablet formulations, starches from taro (TS) and sweet potato (SPS) tubers were prepared with obtained yields of 11.0 and 9.6%, respectively. Both TS and SPS met USP22-NF17 identification and specifications. Their equilibrium moisture contents and gelatinization temperatures were comparable with those of commercial starch, where...
متن کاملEffects of starches on the mechanical properties of paracetamol tablet formulations. II. Sorghum and plantain starches as disintegrants.
This study evaluates the disintegrant properties--tablet disintegration time (DT) and crushing strength--friability/disintegration time (CSFR/DT) ratio of a paracetamol tablet formulation prepared with sorghum and plantain starches in comparison with corn starch BP. The effects of disintegrant concentration, relative density of tablets and the mode of disintegrants addition were studied. The st...
متن کاملEffects of modification and incorporation techniques on disintegrant properties of wheat (Triticum aestivum) starch in metronidazole tablet formulations.
BACKGROUND Natural polymers serve as cheap, non-toxic, biocompatible excipients in drug delivery. OBJECTIVES Starch from wheat (Triticum aestivum) was investigated as a disintegrant in metronidazole tablet formulations in comparison with sodium starch glycolate (SSG), a standard, synthetic but relatively more expensive disintegrant. MATERIAL AND METHODS Native wheat starch (NAS) was modifie...
متن کاملStudies on disintegrant action of Leucaena leucocephala seed gum in ibuprofen tablet and its mechanism
Leucaena (Leucaena leucocephala) seed gum (LSG) was evaluated for disintegrant action in lactose (soluble) based tablets containing ibuprofen, a relatively insoluble drug. The properties of tablets evaluated include weight uniformity, hardness, friability, disintegration time and in vitro dissolution (k, T 50 , A 30 ). LSG, at low concentration level (2% w/w), can be used as a disintegrant in t...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2020
ISSN: 2250-1177
DOI: 10.22270/jddt.v10i5.4324